Defence
Most of the enumeration mixes really well with the normal traffic to the DC.
Hardening can be done on the DC (or other machines) to contain the information provided by the queried machine.
NetCease
NetCease is a script which changes permission on the NetSessionEnum method by removing permission for Authenticated User group.
This fails many attacker's session enumeration and hence user hunting capabilities.
Another Interesting script from the same author is SAMRi10 which hardens windows 10 and Server 2016 against enumeration which uses SAMR Protocol
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